| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76ba102ea9c02b6633d64bf09c5b89a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10679c290832e7325bba7a6ad9edcd15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_117c38c15c47dd1797dfe04535b25108 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-172
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2009-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8290614d882221ff3a6122c9b6c62120
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_661e4d97c89ccb3761795fcbe0db7287 |
| publicationDate |
2010-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010005939-A1 |
| titleOfInvention |
Methods and kits for detecting risk factors for development of jaw osteonecrosis and methods of treatment thereof |
| abstract |
Determining the pharmacogenetic, pharmacokinetic and cellular basis of bisphosphonate-induced osteonecrosis of the jaw (BONJ) via associating particular proteins and particular single nucleotide polymorphisms with a risk for developing BONJ after receiving bisphosphonate treatment. Methods and kits for identifying the genetic basis for a patient's predisposition to BONJ. A haplotype tagging SNP approach was used to analyze candidate genes involved in bone absorption and destruction and to examine the influence of genetic variants on the susceptibility of BONJ. Bone biomarkers of BONJ are disclosed. Said biomarkers provide for improved monitoring of the drugs used to treat BONJ, improved prevention of BONJ, and optimized treatment of patients having BONJ or predisposed to BONJ. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015083163-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2521793-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2694681-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2521793-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012138745-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9273357-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2694681-A4 |
| priorityDate |
2008-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |