| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e39c3fedb6aa1361ff79c8ed5d4a529c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71b944100daf03103e6704d7474fd127 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96494
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-914 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B56-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-0025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-086
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-0066 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate |
2009-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3873310ca65e32cfad7b8f07960cf08d |
| publicationDate |
2010-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010002976-A2 |
| titleOfInvention |
Enzyme-cleavable dye-containing fluor-quencher constructs |
| abstract |
This invention relates to novel compounds that contain a fluor and a quencher linked by an enzyme cleavable substrate. The constructs contain fluor/quencher moieties that are optically silent until cleaved by enzymes, in a preferred embodiment by matrix metalloproteases (MMPs). After cleavage, the constructs become fluorescent - the resulting fluorescent moieties provide imageable emissions that can be used for in vitro evaluation of enzyme activity or for in vivo detection of disease. In a preferred embodiment the fluor is detectable in the hear infrared (NIR). Unlike imaging methods that provide information on morphology, these constructs provide biochemical information about the disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114878725-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114878725-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113683602-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10646591-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022197186-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103242822-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012054784-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3983334-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021198228-A1 |
| priorityDate |
2008-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |