http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009152546-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47ae7d6cf5803bcca959741cbbb31adf http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df5866dc8bccb807413297e9657a6ed5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fda87544d39d72f4fa26201cf1f1ba22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cdb48577f62fd97bad781d9ca6a562fe |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-172 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2008-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d0a1d1882de481f6cbd0083399df153 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91f956751d889f338b0478ef7d2bea01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c27f5424e4d518ca0c5777d8ae4f4bc3 |
| publicationDate | 2009-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2009152546-A1 |
| titleOfInvention | Dopamine-beta-hydroxylase genetic polymorphism and migraine |
| abstract | The invention provides a method of determining whether or not an individual has a predisposition to migraine including the step of determining whether an isolated nucleic acid obtained from the individual comprises a nucleotide sequence corresponding to at least a fragment of a dopamine β-hydroxylase (DBH) gene promoter, wherein the presence of a -1021C → T single nucleotide polymorphism (SNP) in said nucleotide sequence indicates whether or not said individual has an increased predisposition to migraine compared to an individual without the polymorphism. DBH -1021C/C homozygotes are particularly susceptible to migraine. The -1021T allele may exert a protective effect. The method is particularly suited to detection of a predisposition to migraine with aura in females. The invention also provides a diagnostic kit for detecting a -1021C→ T SNP associated with migraine. The method and kit may facilitate selection of individuals for migraine therapy which targets the dopaminergic system. |
| priorityDate | 2008-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.