| abstract |
Provided is a compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, which can be used in pharmaceutical applications, and an agent for blocking GIP receptor binding for preventing or ameliorating obesity, insulin resistance or the accumulation of lipid in the liver, based on blocking GIP function and more precisely based on blocking GIP receptor binding, wherein said compound forms the effective component. [In this formula, for example, W represents CR 1 (where R 1 is a halogen atom or a cyano group) etc., and Z is a group represented by general formula (VI), (V2) or (Y1).] [In these formulae, for example, A represents an optionally substituted aryl group etc., R 2 represents an optionally substituted aryl group etc., R 3 represents an optionally substituted phenylsulfonyl group etc. and R 4 and R 5 represent hydrogen or an optionally substituted alkyl group etc. having 1 to 3 carbon atoms] |