| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5fa9d8301863cb36947ee3320ae4054d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-22053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-22052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2009-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71d253f34d9194b3deb3f8329096f11c |
| publicationDate |
2009-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009145956-A2 |
| titleOfInvention |
Uses of calpain inhibitors to inhibit inflammation |
| abstract |
Calpains target junctional components that normally seal the epithelium, forming tight junctions. This selective targeting by calpains facilitates the transmigration of leukocytes across the epithelium and into tissue spaces where they can cause inflammation. The present disclosure provides methods of using calpain inhibitors to prevent epithelial junction reorganization such that leukocyte transmigration is inhibited and accordingly, inflammation reduced or prevented. These methods can at least be used to reduce respiratory inflammation by preventing leukocyte accumulation in pulmonary airways. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10828350-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10857233-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9486513-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015066212-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4166136-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10954521-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023062219-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107929274-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9737592-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10364435-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11219671-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11180535-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9878023-B1 |
| priorityDate |
2008-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |