| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e4945b93ab6009360a1219494171302
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b4a80ac02f1ecd0e698ec665e9b36b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a6f4f0c4c01d40b9690f65da75934320
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8348e32d6209f3cb66ebd4fe3ee8720
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_851400295240de7caba2c6bfbaf2ed2e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_132b919e0c37b88f9723822b94e739bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_86eba0dc59456cd0312e65e1461ab27e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ee5bf368c1e200314ddb84dd830e73f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 |
| filingDate |
2008-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3cc072a8ade65c360eeca8fa4ea4074
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bf909d673d649ec85c51f46af8a0649
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20e9cf5ad8b94afd1a6b7d6e5ddfa37a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_455aa81ed7e6f9b6329dbafa9a6c05ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eab82fbbd5bc3fc23b9744a1a0a7c5ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3f2bc2fbadb40d1359e2c113e98436d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4326498bb7c846ca92cbac7c7d96bedc |
| publicationDate |
2009-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009145368-A1 |
| titleOfInvention |
Improved preparing method of (s)-omeprazole from omeprazole racemate using optical resolution agent |
| abstract |
The present invention relates to an improved preparing method of ( S )-omeprazole from omeprazole racemate. In an exemplary embodiment, the preparing method according to the present invention comprises the steps of: a) reacting omeprazole racemate with optically active diethyl-D-tartrate and a titanium compound in an alcohol solvent to prepare an omeprazole racemic complex; b) reacting the omeprazole racemic complex with 1.5-3.0 molar equivalents of ( S )-(+)-mandelic acid as optical resolution agent to prepare an optically active ( S )-omeprazole complex; and c) dissociating the optically active ( S) -omeprazole complex with a basic solution to prepare an ( S )-omeprazole free base or reacting the ( S )- omeprazole free base with a metal salt to transfer to a metal salt or a metal salt hydrate of ( S )- omeprazole. With optical purity of 99.0 %ee or better, the ( S )-omeprazole, the metal salt thereof or the hydrate thereof prepared in accordance with the present invention is useful as a medicinal material. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101459088-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102964335-A |
| priorityDate |
2008-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |