| abstract |
The present invention provides an improved process for preparing fexofenadine, its pharmaceutically acceptable salts and solvates thereof, the process comprising reacting methyl-4-(4-halo-1-oxobutyl]-α,α-dimethylphenyl acetate with α,α-diphenyl-4-piperidinemethanol in an alkyl nitrile solvent to prepare 4-[4-(4- (hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α,-dimethylbenzene acetic acid alkyl ester, which is further converted into fexofenadine. |