| abstract |
The present invention relates to a combination comprising one or more antimycotic agent(s) selected from the group of amphotericin B, nystatin, griseofulvin, primycin, terbinafine, an azole type one and one or more statin(s) selected from the group of lovastatin, simvastatin, fluvastatin, pravastatin, rozuvastatin, atorvastatin, cerivastatin, pitavastatin, for the use as an agent inhibiting the growth of fungi, furthermore, relates to a combination composition having antimycotic effect comprising a clinically acceptable dose of a combination of an antimycotic agent and a statin selected from the group of (i) amphotericin B and rozuvastatin, (ii) amphotericin B and pitavastatin, (iii) primycin and rozuvastatin, (iv) primycin and cerivastatin, (v) primycin and pitavastatin, (vi) voriconazole and simvastatin, (vii) voriconazole and pravastatin, (viii) voriconazole and atorvastatin, (ix) voriconazole and cerivastatin, and optionally one or more pharmaceutically acceptable excipients as well as relates to the said combination composition formulated as a medicine.˙ |