| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1663261f99149e1f556586dcd9b05e4d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f2ad6b4d4081ba2d8724466631ab640
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c933a5971f862f869ecffd5732efcf88 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-12 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2009-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab59fd216ce49746c21f407cf07de7ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_990526ae07fcf0b28afb7c031e214ec9 |
| publicationDate |
2009-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009134418-A2 |
| titleOfInvention |
Assay for identifying agents that modulate epigenetic silencing, and agents identified thereby |
| abstract |
A high throughput RNAi-based assay for identify factors involved in maintaining epigenetic silencing is disclosed. The assay measures reactivation of a silent reporter gene in cells, resulting from RNAi-based knockdown of target mRNA. RNAi-based screening of these silent reporter cells has identified known enzymes that place or remove epigenetic marks on histones, as well as non-enzymatic proteins that function in silencing or in transfer of marks during S-phase. In addition, the screen has been used to identify a number of novel gene products involved in epigenetic silencing, which are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11197881-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109321572-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016007909-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020214809-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016172734-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1877555-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11249071-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011080314-A3 |
| priorityDate |
2008-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |