| abstract |
The invention relates to compounds having the Formula (I), wherein the dashed line (represented by - - - - - ) represents an optional double bond; R 1 is hydrogen and R 2 is hydroxyethyl; or R 1 and R 2 together with the nitrogen atom to which they are attached form a morpholinyl ring optionally substituted with one or two hydroxy groups; each R 3 is independently hydroxy or Ci-εalkoxy; n is selected from 0, 1, and 2; or a N-oxide, salt, prodrug, solvate or stereoisomer thereof; with the proviso that the compound where the dashed line represents a double bond, R 1 and R 2 together with the nitrogen atom to which they are attached form a morpholinyl ring, and n is 0, is excluded. Also provided are methods for the preparation of compounds of formula (I); their uses as a medicaments, particularly for the treatment or prophylaxis of a sigma receptor mediated diseases or conditions. |