| abstract |
Disclosed is a method for preparing a compound of Formula (1) wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula (2), a compound of Formula (3), a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula (4) wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula (4a) wherein M 1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula (2) comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula (5) wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula (6) wherein Y is OR 11 or NR 12 R 13 , and R 11 , R 12 and R 13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula (7) wherein Q and Z are as defined in the disclosure, using a compound of Formula (1) characterized by preparing the compound of Formula (1) by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above. |