| abstract |
Disclosed is a novel compound having an inhibitory activity on a plasminogen activator inhibitor-1 (PAI-1). Also disclosed is a PAI-1 inhibitor comprising the compound as an active ingredient. Further disclosed is a pharmaceutical composition effective for the prevention or treatment of various diseases whose occurrence is associated with a PAI-1 activity. The pharmaceutical composition comprises the compound having an inhibitory activity on a PAI-1 as an active ingredient. The novel compound has a basic skeleton represented by the formula. In the formula, B represents a carboxylic acid or a biological equivalent group thereof. |