| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c592009b8c77c96c2b19b855287b374
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_659126995f1293c310553b159743bb0c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbd436cd7f986d0697a8e7053ba55f8d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d0fdf7e8538a3e5866347798c658cb04 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0077 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 |
| filingDate |
2009-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19f3da3e688520ff9759e791cd5a6e9b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c789c3da7abff11c75897dac72baeba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8089800548b639f280532343dee6f1a |
| publicationDate |
2010-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009120678-A3 |
| titleOfInvention |
Birch reduction of steroid substrates via alkali metal-silica gel materials |
| abstract |
Steroids are well known, medicinal relevant, chemical entities. There are numerous steroids which have fully or partially reduced 1A' rings. These fully or partially reduced 1A' rings have been reduced in the past through Birch and other dissolving metal reductions. Novel reducing conditions for steroid substrates are described which utilizes stabilized alkali metal - silica gel materials. The invention relates to a method for reducing a double bond within a steroid by contacting an unsaturated steroid having a phenyl ring with a Stage 0 or Stage I alkali metal - silica gel material in the presence of a proton source under reaction conditions sufficient to form a reduced steroid having a diene structure. |
| priorityDate |
2008-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |