| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55ba9e834829fe506b41cf04d1fcbbac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e3830f35387a1c32061dea3ee310851
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72fa31f6c7a53141bddbcf0d3131a2e7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e66da3c34c8e5a80edd25bcb8e1b1416 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 |
| filingDate |
2009-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ce5bdfac2700c4a284a5125a08a7f02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc3548342ee0499ca009f545b3f78d8c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_115d41a53c0a0c1bad4269922a321d64 |
| publicationDate |
2009-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009114459-A3 |
| titleOfInvention |
Anti-neoplastic combination therapy comprising co-disruption pathway and mre11/rad50/nbs1 complex and compositon thereof |
| abstract |
An anti-neoplastic method is provided which involves a combination therapy involving delivery a PARP inhibitor in a regimen with a disruptor of the Mrel l/Rad50/Nbsl complex. The disruptor of the Mrel l/Rad50/Nbsl complex may be an Nbsl construct or a mutant Rad50 construct and either, or both, may be delivered via a viral vector carrying the coding sequences for one or these constructs. A replication-defective adenovirus containing the mutant Rad50 construct is also provided. |
| priorityDate |
2008-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |