http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009114096-A1

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filingDate 2009-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2009-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2009114096-A1
titleOfInvention Systems and devices for modulating autonomic tone
abstract Various system embodiments comprise means for intermittently delivering a sympathetic stimulus, including means for delivering a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing. The stress-inducing pacing results in a parasympathetic reflex after the sequence of stress-inducing pacing. The embodiment further includes means for delivering neural stimulation to elicit a parasympathetic response or a sympathetic response in a coordinated manner with respect to the sequence of stress-inducing pacing pulses. The neural stimulation is timed to elicit the parasympathetic response after the sequence of stress-inducing pacing pulses and concurrent with at least a portion of the parasympathetic reflex to the sequence of stress-inducing pacing to enhance a parasympathetic effect of the parasympathetic reflex, or to elicit the sympathetic response during the sequence of stress-inducing pulses to provide a larger sympathetic stimulus, resulting in an enhanced parasympathetic reflex in response to the large sympathetic stimulus.
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