| abstract |
Disclosed is a method for preparing a compound of Formula (1) comprising contacting a compound of Formula (2) with a metal cyanide reagent, a copper (I) salt reagent, an iodide salt reagent and at least one compound of Formula (3), wherein R 1 is NHR 3 or OR 4 ; R 2 is CH 3 or Cl; R 3 is H, C 1 -C 4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R 4 is H or C 1 -C 4 alkyl; X is Br or Cl; and R 5 , R 6 , R 7 and R 8 are as defined in the disclosure. Also disclosed is a method for preparing a compound of Formula (4) wherein R 11 , R 12 , R 13 and Z are as defined in the disclosure, using a compound of Formula (1) characterized by preparing the compound of Formula (1) by the method disclosed above or using a compound of Formula (1) prepared by the method disclosed above. |