| abstract |
The present invention provides the compounds conforming to the formula (I) in which: R represents a (C 1 -C 6 )alkyl or halo(C 1 -C 6 )alkyl group; R' represents a group NR4R5 or OR8; A and B, when present, represent independently of one another, one or two carbon atoms, these carbon atoms being substituted by one or more hydrogens or (C 1 -C 6 )alkyl groups; the (C 1 -C 6 )alkyl group or groups being optionally substituted; A+B represent two carbons at most; R1 represents a hydrogen atom or a (C 1 ‑C 6 )alkyl group; R2 and R3 represent, independently of one another, a hydrogen atom or a (C 1 -C 6 )alkyl group; the (C 1 -C 6 )alkyl group being optionally substituted; R4 and R5 represent, independently of one another, a hydrogen atom or a (C 1 -C 6 )alkyl group, or form, with the nitrogen atom which carries them, a heterocycle of the azetidine, pyrrolidine, piperidine, azepan, piperazine, homopiperazine, morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide type, this heterocycle being optionally substituted by a (C 1 -C 6 )alkyl group; R6 and R7 each represent a phenyl group, which is optionally substituted; Y represents a hydrogen atom, a halogen or a (C 1 -C 6 )alkyl group, halo(C 1 ‑C 6 )alkyl, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkylS(O) p or cyano group; R8 is a hydrogen atom, a (C 1 -C 6 )alkyl group, a halo(C 1 ‑C 6 )alkyl group, an allyl group or a phenyl(C 1 -C 6 )alkyl group, the phenyl group being optionally substituted by 1 or 2 O-methyl groups; p represents an integer selected from 0, 1 and 2; in the form of the base or an addition salt with an acid or with a base. Preparation process and application in therapy. |