| abstract |
The invention relates to the use of a N-benzyl 5-substituted imidazole derivative having the general formula (I) wherein R is (C 1-3 )alkyl, (C 1-3 )alkyloxy, halogen, nitro or cyano; R 1 is formyl, (C 1-6 )alkyl, optionally substituted with OH, (C 1-3 )alkyloxy, (C 1-3 )alkylcarbonyloxy, (C 1-3 )alkyloxy- carbonyl or halogen, or (C 1-3 )alkyloxycarbonyl; or R 1 is phenyl, optionally substituted with 1 -3 substituents independently selected from (C 1-3 )alkyl, (C 1-3 )alkyloxy, hydroxylmethyl and halogen; or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of a disorder or disease in a subject mediated by aldosterone synthase or responsive to inhibition of aldosterone synthase. |