| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f3e3523d0d029abbd841f3e54530dd7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e1481d15afd3f2bb0d80d68891710295
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d4260a256b5f28ea7d92b4c1f5b921d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ca151330513e18c6bde373050e0dc43 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1133
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-13 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 |
| filingDate |
2009-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5273d6709fda04499cc9e2e6cc320952
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25dbe6fef5aa6eca147803e74471c0e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_038e0aa38c070230d07c56473d086977 |
| publicationDate |
2009-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009103941-A1 |
| titleOfInvention |
Chemical modification of proteins |
| abstract |
The invention relates to methods for selectively converting a cysteine residue in a peptide or protein to the dehydroalanine (Dha) residue. The method also works on selenocysteine and substituted cysteine and selenocysteine residues, resulting in the Dha residue which may be converted to any natural or unnatural amino acid residue desired without the alteration of the remainder of the peptide or protein. The invention also allows ligation of a desired peptide at any point rather than at a point where there should be a naturally occurring cysteine, thereby allowing native chemical ligation to be used in the synthesis of peptides that do not contain cysteine. The methodology allows for the synthesis of very large peptides. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3871665-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013084198-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009147414-A1 |
| priorityDate |
2008-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |