| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ebd797bfaa34db34a988df9c05400295
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a824e02dcf388b9241cfe71a79f4602c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7775dfe81038436a494409a1b25eb404 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C221-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-24 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C225-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C221-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-04 |
| filingDate |
2009-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e085dddef8437228a72abbc466f90a27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e5b23b948f7fe065c1d288756265ef3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbf3a5e7707bcb3db28fe8acb987365b |
| publicationDate |
2009-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009100996-A2 |
| titleOfInvention |
Process for preparing pyrazole functionalized benzodiazepinones |
| abstract |
The present invention provides innovative strategies for synthesizing pyrazole ring- functionalized benzodiazepinones. Alternative intermediates and high conversion strategies for forming alpha-aminobenzophenone intermediates involve a combination of aromatic acylation, displacement of electronegative leaving groups with amine, and then N-displacement strategies to produce the desired alpha-aminobenzophenone with primary amine functionality. Reaction strategies are then provided for converting alpha-aminobenzophenones to alpha- amino amidobenzophenone intermediates with high yield and convenient reaction strategies. These alpha-aminoamidobenzophenone intermediates are then converted into benzodiazepinones. These benzodiazepinones are then converted to pyrazole ring functionalized benzodiazepinones through a series of innovative intermediates and/or reaction strategies. |
| priorityDate |
2008-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |