| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b7d8339c22da8ef2d3c4bfa490801777
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7d3ffbe74c255811a30126cc64bc6a82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_32b3c0fe52d546201f517685017c5e32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_237c5b9e244d7a068193cc4e68619112
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac9442e962452275a63c777abad46223
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d994c2c6cce49eb974437d6999f00a3a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4392e86d275952e8009068cf353d8464
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad24b6d57110cafae62e6e8bdefb0182
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_446f31e6bb0092e3e6c76a7038a14751
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_baaf3b2b9e2d5596afd1689177240a32 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-11002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-48 |
| filingDate |
2009-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d21a09780bb1ded968b925a8967225a9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de600b3d02164e393b7ec91fc9939f15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45626bfa1c56155dd167796d5f11101f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53ec1f572b9f833d890ed7c15e9817c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9d8cdbaf5bb31bd84176fbffd44d064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_707a18268af604499211263636d067b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7192549d6c546f0e03c345076af50311
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_580922f7b5319f823d4f612637c55cb5 |
| publicationDate |
2009-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009100489-A1 |
| titleOfInvention |
Crystal structure of pfa-mi and the pfa-mi co4 complex |
| abstract |
The invention relates to the X-ray crystal structure of PfA-M1 aminopeptidase alone, and in complex with the phosphinate dipeptide analogue hPheP[CH2]Phe. More specifically the present invention provides the structure coordinates of PfA-M1 and PfA-M1 in complex with Co4. The invention also includes the use of the X-ray crystal structures as drug target models for anti-malarial drug design and a method for identifying or designing novel anti-malarial drugs, for example using high-throughput chemical screening and medicinal chemistry methods. The invention further provides anti-malarial drugs identified or designed according to the aforementioned method and their use for obstructing protein metabolism and synthesis in a parasite by blocking the entrance of Hb- derived peptides and/or blocking the exit of released amino acids at the active site of PfA-M1 protease. |
| priorityDate |
2008-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |