| abstract |
The invention relates to the pharmaceutical technology field, especially relates to pyrazolopyrimidinone-containing phenyl guanidine derivatives represented by formula I, pharmaceutically acceptable salts or solvates thereof. The invention also relates to pharmaceutical compositions containing such compounds and the preparation of such compounds. The compounds have stronger inhibitory effect against phosphodiesterase V than sildenafil, and have higher selectivity than to phosphodiesterase VI which distributes in retina, thus can be used in the treatment for vascular disorders such as erectile dysfunction of male. |