| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c999fee6428152a996011d506925c2d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_46b05a9bc024b70a097e6beac764ee7b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_204697648dccbe07bb4cd05049f8405d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-14 |
| filingDate |
2009-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a7c80b15354043b1d89150de0db7f8a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_640b84517727e8b317408f2bbe9d43f0 |
| publicationDate |
2009-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009096572-A1 |
| titleOfInvention |
Process for production of nucleic acid derivative and intermediate compound thereof |
| abstract |
Disclosed is an industrially advantageous process for producing a nucleic acid derivative (e.g., an L-thymidine) and an intermediate compound of the nucleic acid derivative. Also disclosed is a novel intermediate compound which is useful for the synthesis of a nucleic acid derivative. An arabinoaminooxazoline compound is treated with a base, protected and haloganated to produce a 2'-halogen-5,6-dihydrouridine-5-exomethylene form. The exomethylene form is isomerized to produce a 2'-halogen-thymidine compound. The 2'-halogen-thymidine compound can be dehalogenated and deprotected to produce thymidine. Alternatively, the 2'-halogen-thymidine compound may be treated with a base to produce a 2,2'-anhydroarabinosylthymine. |
| priorityDate |
2008-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |