| abstract |
13,13-Dimethyl-flfes-C,D analogs of la,25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms thereof, and methods of treating skin conditions thereof. Exemplary active pharmaceutical ingredients include (lR,3R)-5-[(E)-(S)-11'-hydroxy- 5',5',7',11 '-tetramethyl-dodec-2'-enylidene]-2-metylene-cyclohexane-l,3-diol, (lR,3R)-5-[(Z)-(S)-11 '-hydroxy-5',5',7',11 '-tetramethyl-dodec-2'-enylidene]-2-metylene-cyclohexane-l,3-diol, (lR,3R)-5-[(E)-(R)-l 1 '-hydroxy-5',5',7',11 '-tetramethyl-dodec-2'-enylidene]-2-metylene- cyclohexane-l,3-diol, and (lR,3R)-5-[(Z)-(R)-11'-hydroxy-5',5',7',11'-tetramethyl-dodec-2'- enylidene] -2-metylene-cyclohexane- 1,3 -diol. |