| abstract |
Thienopyridazine compounds of formular (I), their pharmaceutically acceptable salts or hydrates, wherein R1 and R2 is separately H or C1-4 alkyl, R3 is a saturated or unsaturated 5- or 6- membered ring containing N, S or O, or its optical isomers, R4 is halophenyl monosubstituted or disubstituted at any position. And the preparation methods of these compounds, pharmaceutical compositions containing these compounds and the uses of these compounds, particularly in treating cancer. |