| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1d57514e2d64378ac1fb41f84b6b207f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c841b7aa14f02e2868c3d17054b1475d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07b9e5c0f0d656d4cb07ac1f07b3adae |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6857 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-534
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate |
2008-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c535e113318e17d61db9f2c9b376d12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ad20008327be9778779d4de2b30437b |
| publicationDate |
2009-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009091240-A1 |
| titleOfInvention |
Method and kits for detecting antibodies against therapeutic antibodies |
| abstract |
The invention relates to the field of immunology and immunological diagnostics. More specifically, it relates to detection of the formation of antibodies in a subject that is treated with a therapeutic antibody. Provided is A diagnostic method for determining the presence of IgG antibodies against a therapeutic antibody in a subject, comprising the steps of: a) providing a solid carrier capable of binding the constant region of IgG antibodies; b) isolating a sample from a subject to be tested for the presence of IgG antibodies against a therapeutic antibody; c) incubating said carrier with said sample under conditions suitable for immobilizing IgG antibodies on said solid carrier; d) incubating said immobilized antibodies with an antigenic fragment of said therapeutic antibody under conditions that allow for complex formation between at least part of said immobilized antibodies and said antigenic fragment, said fragment lacking a constant region and being conjugated to a detectable label; and wherein said incubation is performed in the presence of an unlabeled antigenic fragment of a non-therapeutic antibody lacking a constant region. Also provided are kits for use in such a method. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9506920-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012175201-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10794906-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11215623-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8865417-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9465027-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011095636-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10386366-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014508930-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011135024-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106164670-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106164670-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8574855-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102854160-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9784748-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10422807-B2 |
| priorityDate |
2008-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |