| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f98194a9fae6f06192f5b6612edc3334
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7ed612c3eacb2ea4633817a85ae10766
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_39707379aed54a34d5d5232975ae834d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-02 |
| filingDate |
2008-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3d53706fb83ac92bab2715e86068c35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae96f5f457dd87ab53df1f113a5f9094 |
| publicationDate |
2009-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009087666-A2 |
| titleOfInvention |
An improved process for production of bicalutamide useful in the treatment of prostate cancer |
| abstract |
The invention relates to an improved process for production of Bicalutamide useful in the treatment of prostate cancer by oxidizing N[4-Cyano-3-trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methyl propanamide with Hydrogenperoxide in the presence of ethylacetate as solvent, methanesulfonic acid and sodiumtungstate as catalysts, washing the reaction mixture with sodiumthiosulphate solution or sodium metabisulphite solution, charcolising and evaporating the reaction mixture adding hydrocarbon solvent, cooling to room temperature and filtering. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109456227-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8895772-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013274501-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012042532-A1 |
| priorityDate |
2008-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |