| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51dadf9b4341695832f4aa8aa7779e3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac1a708ac402c2584f092facfedab160
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_162720da2ff61dfc39b94f162125caf5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a610d9fcf1be4527398ce313c06c9df
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_646aef1317c349061a2098fab5f4f5ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c18f80aa9fe252508d428e3574d4016
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_392531df415618b7f49add6d8199146f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0fb2070ec3c3b4c599887dd005e76e8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-32 |
| filingDate |
2008-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40296d2263ac0ffd78f14af232d908ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3efeea1b4aff3ea346eb9fe34d9d4bbf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a45bf9b5c7b67eefbf515c8580cab951
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a20581c6bf115e780a72849519ad242
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84fa338df7ef667e861a9b491df35a7f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7840e573b83f64c7d1936c0ac8fa4ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84ea3aca902ff0fd5ff6d5865c2b9194 |
| publicationDate |
2009-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009087650-A3 |
| titleOfInvention |
A novel process for synthesis of pregabalin from substituted cyclopropane intermediate and a process for enzymatic resolution of racemic pregabalin |
| abstract |
A novel process of preparation of racemic pregabalin from comprising an intermediate of structure III comprising reductive ring opening to form a structure IV followed few alternative routes that yield racemic pregabalin that is resolved to yield (S) + pregabalin by using chemical or enzymatic methods. A new chemical entity of structure IIIc is also disclosed as a novel intermediate. A part of the novel process also comprises a new process of producing a compound of structure VII comprising acylation of compound of structure V followed by elimination and improving a process of producing a compound of structure VII comprising reacting isovaleraldehyde with nitromethane through the compounds 4-methyl-1-nitropentan- 2-ol, 3-methyl-1-(nitromethyl)butylacetate, and 3-methyl-1-(nitromethyl)butyl acetate under suitable conditions to 4-methyl-1-nitropet-1-ene. Enzymatic processes of resolution of racemic pregabalin esters into (S) pregabalin and (R) pregabalin are also disclosed. |
| priorityDate |
2007-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |