| abstract |
The present invention relates to a composition for the prevention and treatment of various cancers, which inhibits protein phosphatases, containing a pyrimidine derivative as an active ingredient. The pyrimidine derivatives according to the present invention effectively inhibit the activities of protein phosphatases, such as Cdc25A and Cdc25B, and may be useful in the prevention and treatment of breast cancer, rectal cancer, non-Hodgkin's lymphoma, prostate cancer, pancreatic ductal adenocarcinoma, lung cancer, bone marrow cancer, and the like. |