| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84bf3df3c637864eb72d38d2bb2eee7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d17663f8447ad0d0d0642d05d4aaee5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2233d03b76de6fd0acd55f109774f32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_415f2323755cbc2b5a625d5f97d266ba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7a810271522bcc944e24fc5253d8f002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_785523d34e93a7ea29e620335d3ca530
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ea8fcd898440feab736404136a8d8ef6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16664 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-08 |
| filingDate |
2008-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9341c9ac81eefba750199f1cc7afdf7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_114051d4d7a04b108d05bc61634c708c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_907f554eb7eceed986d8f25d869555ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d1d2408b6f61f06f5d2828f662f6af4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c81fe20290f4177d967f462f43d0039 |
| publicationDate |
2009-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009066247-A1 |
| titleOfInvention |
A process for preparing attenuated viral strains |
| abstract |
A process for preparing attenuated viral strains, comprising to contact, at least one sulphated polymer and a virus susceptible to the inhibition of said polymer, via successive passages of the virus with increasing polymeric concentrations, where said amenable virus is characterized by the method of reducing viral plates and where the strain resulting from the attenuated virus has stable phenotypic and genotypic characteristics, different from that of the virus strain in wild state that generated thereto. The process comprises to contact the sulphated polymer (s) with the virus susceptible to the inhibition of said polymer via about 15 or more successive passages with increasing concentrations of said sulphated polymer (s). According to the inventive process, the concentration of said at least one sulphated polymer in the first passage should be less than the IC50 of said polymer for the amenable virus when it is found in wild state. Use of the attenuated viral strains through the above mentioned process in the preparation of vaccines and pharmaceutical compositions. |
| priorityDate |
2007-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |