http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009064290-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a933a0dd561e3e50b278738704d5c6e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1fff0cc6a315f5648273fefd9b7a0168 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_70c34ce389c077a4cc5fc22c7f1d8920 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4df40bca3cd1de348de19eb9cb2eadf9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70503 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2007-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83aace3959a28d3c5c7b7eb972bf6dda http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b814e93a80167aaa1e5048866dcc988 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e5c7b797e05e28f8e0030a67afd5d99 |
| publicationDate | 2009-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2009064290-A1 |
| titleOfInvention | Structure of tim family members |
| abstract | The present invention provides crystal structures of the N-terminal Cys-rich Ig-like ligand-binding domain of the murine Tim-1, Tim-2, and Tim-4 receptors and models for the murine Tim-3 receptor and the human HAVCR1/TIM1, TM3, and TIM4 receptors based on the said crystal structures, and so provide materials and methods for identifying mimetics of the natural ligands for these receptors and also antagonists of those ligands. The structures also reveal a homophilic interaction for each receptor, which is confirmed biochemically. This invention provides materials and methods to target specific mutations on the TIM family receptors based on their crystal structure to modulate (enhance, reduce, or inhibit) homophilic and/or heterophilic interactions as well as binding to natural ligands. The resulting TIM receptor mutants could be used as therapeutic agents. Thus, the invention also provides materials and methods for identifying agonists and antagonists of TIM family members homophilic and heterophilic interactions. HAVCR1/TIM1 is the receptor for Hepatitis A Virus, and thus the invention also provides materials and methods for identifying inhibitors of HAV infection. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10912828-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10639368-B2 |
| priorityDate | 2007-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.