| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f7b15f0234e1d475096bafa5a17f16b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4f13a80c79a1aa1b326f81158e9aac3e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8129548f7ec81010b5ca721964babd2a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_31ae4a4d0fbe6bf19e4a672517bded7d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a415bee96e2a1c1df8a67849a2cb2c3b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c8cdf59ab2945f4bc4dfdb27d87fdcb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-09 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52 |
| filingDate |
2008-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9077ed69d68ea61f455c21086f30650f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01ff40b76d737a5d3138efe63f911a9d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_603c4f73e575184bc81de2031c0da703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c7c6347c698bdb72fe1f60a1ddb2f65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_078419db0dd25c7b62e9947bb466a2d4 |
| publicationDate |
2009-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009061130-A2 |
| titleOfInvention |
Cell permeable runx3 recombinant proteins, polynucleotides encoding the same, and anticancer compositions including the same |
| abstract |
The present invention discloses cell permeable RUNX3 recombinant proteins where a Macromolecule Transduction Domain (MTD) is fused to a tumor and metastasis suppressor RUNX3. Also disclosed are polynucleotides encoding the cell permeable RUNX3 recombinant proteins, an expression vector containing the cell permeable RUNX3 recombinant protein, and a pharmaceutical composition for preventing metastasis which contains the cell permeable RUNX3 recombinant protein as an effective ingredient. The cell permeable RUNX3 recombinant proteins of the present invention can induce the reactivation of TGF-β signal transduction pathway which causes cell cycle arrest by efficiently introducing a tumor and metastasis suppressor RUNX3 into a cell. Therefore, the cell permeable RUNX3 recombinant proteins of the present invention can be effectively used as an anticancer agent capable of preventing cancer growth and metastasis by suppressing the proliferation, differentiation, and migration of cancer cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9067984-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9040246-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10494402-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9388242-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9617337-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10766927-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9695419-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10844102-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015284433-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8741289-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE47672-E
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8540988-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8900579-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9493562-B2 |
| priorityDate |
2007-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |