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publicationDate 2010-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2009050734-A9
titleOfInvention An industrially feasible process for the manufacture of bisquinoline derivatives by using substantially pure n-monosubstituted piperazines
abstract A process for the preparation of substantially pure 7-chloro-4-(ρiρerazin-1-yl) quinoline of formula (II) free from dimer impurity of formula (III) and process for the preparation of substantially pure piperaquine and its acid salt by using pure 7- chloro-4-(piperazin-1-yl) quinoline.
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