| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f1e187171c6b5eb153898cc420c49281
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51145b66d0ef336da9a5346420f59f58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6bfeccb4747eed95a30c4123771289fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc1d813f9f84e858c46bf3119eda41ae |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-172 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
| filingDate |
2008-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae84ec6eed05f93aa415a7b50ef5c5e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a415d512526cb7ae6f07231c38abd5e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ba0b4a8a3dfe9f36e22e5ca8d0a7a46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b70612deefeb48c47393e9279e0c651 |
| publicationDate |
2009-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009042680-A2 |
| titleOfInvention |
Detection of mutations in acta2 and myh11 for assessing risk of vascular disease |
| abstract |
A method of detecting in an individual an increased risk of hyperplastic vasculomyopathy, or a vascular disease resulting therefrom is disclosed. The method comprises obtaining a DNA genome sample from the individual and detecting in the sample a missense mutation in a gene which is a component of a smooth muscle cell contractile unit. In some embodiments the gene is ACTA2 and in some embodiments the gene is MYH11. In some embodiments, the gene is sequenced and then compared to a panel of control gene sequences which are representative of the same gene in individuals without vascular disease or who are at low risk of developing hyperplastic vasculomyopathy, to detect any missense mutations in the gene. The presence of a missense mutation in the gene indicates an increased risk of hyperplastic vasculomyopathy. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-5854423-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011049207-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113430229-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010259390-A |
| priorityDate |
2007-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |