| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e65ba57390a9b22cff12e1ade78c8ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf2380e07172f31e9723231d4794ad87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05b993887652163a78a888d6e7e41ae7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a742ed559a188e3cb187177027829a1a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7449ca99fbf1c556219fe28876cbf2a9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7db088a1cef40f4f0e03a2468c1fefac |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-12 |
| filingDate |
2008-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa1b719254386309721801ba2343b811
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d98c44562104a1dea977eb9f0510d77e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_661384bb64381cf0689c7c5cc27d8a23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_770c5297086eb645a594de128335bbae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12fcdaffbb79d7f811308dc94f7cb4a9 |
| publicationDate |
2009-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009039188-A1 |
| titleOfInvention |
Peptides and methods for the treatment of gliomas and other cancers |
| abstract |
The invention is based on the discovery that STM /Hop promotes proliferation of human glioblastoma-derived cells but not of normal astrocytes and that the proliferation requires the binding of STM /Hop to PrPc. The invention is directed to methods for treating cancer which rely on interfering with the Hop-PrPc interaction and to peptides, and antibodies raised against the peptides, which directly provide that interference. The invention is further based on the discovery that STI1230-245 peptide and its human homologue Hop23o-245 provide the desired interference with the STI1/Hop-PrPc interaction and inhibit the STI 1/Hop-induced proliferation of glioma and glioblastoma cells. The invention is thus further directed to methods of treating cancer that employ these peptides and functional derivatives thereof, and antibodies directed to the peptides and derivatives. The invention is further directed to means of treating cancer which involve reducing the effective amount of Hop or reducing the expression of Hop. The invention is further directed to means of alleviating or eliminating the side effects of drug therapy and radiotherapy used in treating patients with brain cancers. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012529272-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7902156-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8546320-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9221867-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010055929-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9365634-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8921314-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9713646-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9161988-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9173891-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103819564-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9914754-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10980892-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8969310-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8853353-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010142035-A1 |
| priorityDate |
2007-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |