| abstract |
The present invention provides a tnaluronidase. The hyaiuronidase can be produced by the strain Streptomyces ai-tinocidm 77, Exemplary characteristics of the hyaluronidase include specific C -terminal or other amino acid sequences, including full-length sequences, and improved physico-chemical and actix itj properties as compared to known h> alυronidase preparatkiiis. Described are also various uses of the hyaiurυnidasc, including topical administration of the h> aiuronidasc to improve skin penetration of a co-administered active substance. |