| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6ca6b02403ff0f3c8ff047a42bef888a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2008-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0633aa8875db4060cc97d5ddcaea5a4d |
| publicationDate |
2009-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009036338-A2 |
| titleOfInvention |
Methods for addressing ocular diseases through interference with the wnt signaling pathway |
| abstract |
Choroidal neovascularization (CNV) in age-related macular degeneration (AMD) is a leading cause of blindness. Very low-density lipoprotein receptor gene knockout (Vldlr/-) mice have been shown to develop subretinal neovascularization (NV) with an unknown mechanism. The present disclosure presents novel methods for addressing eye-disease states characterized by angiogenesis or neovascularization by inhibiting the wnt signal pathway. Inhibition of the LRP5/6 receptor by an agent, for example DKKi or antibody, is shown to inhibit the wnt pathway effecting reduction in ocular neovascularization and angiogenesis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-028202-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013109819-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9200072-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10035854-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015511119-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104066449-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9522954-B2 |
| priorityDate |
2007-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |