| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c58c26b9bd0523e8cf0b8dfbd0229f83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c00e94a69923603f03e0fb3a8ba40cc4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e786c3d0d2ad574061f0a1d9fa2d1c8a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-208 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate |
2008-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cde1ee19742cc97e1a2d38890ec3a52f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ced930554fe7f545e2546a3da958774 |
| publicationDate |
2009-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009033653-A1 |
| titleOfInvention |
De novo formation of artificial chromosomes in primary cells and their uses in xenotransplantation, cell and gene therapy |
| abstract |
The present invention relates to methods for introducing multiple transgenes into a primary cell as well as to methods for producing multi-transgenic primary cells, tissues and/or animals by utilizing nucleic acid constructs that are capable of de novo formation of artificial chromosomes. The present invention furthermore relates to uses of these multi-transgenic primary cells, tissues and animals, preferably in the context of xenotransplantation. The nucleic acid constructs capable of de novo forming artificial chromosomes are utilized as versatile and effective means for the transfer of multiple human transgenes and, thus, ultimately for the generation of animals as organ donors in xenotransplanation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102008063592-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012156721-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8945876-B2 |
| priorityDate |
2007-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |