Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bd0e7ae97b521775f63a5aafe5d81dc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42bd8c170a9381e799c4b58962b138ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc4209078d025bee83bc1ad02a70fcf2 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-084 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-026 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-086 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-08 |
filingDate |
2008-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17872405624c7a9b16e3693e9b764bc4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7aaaaf27b5ba4fe317063934a2060a75 |
publicationDate |
2009-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2009032181-A2 |
titleOfInvention |
Methods and intermediates for chemical synthesis of polypeptides and proteins |
abstract |
The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal β-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a β-amino-thioester intermediate that spontaneously rearranges to form an amide bond. The invention also relates to methods of synthesizing β-methyl-cysteine (SEQ ID NO: 1) and its protected forms. Furthermore, the invention relates to converting a β-methyl-thiazolidine residue to a β-methyl-cysteine (SEQ ID NO: 1) residue of polypeptides and proteins. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9175053-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2534168-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2534168-A2 |
priorityDate |
2007-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |