| abstract |
Certain pyrimidine compounds are disclosed as Toll-like receptor (TLR) agonists. The compounds of the invention and pharmaceutical compositions including the compounds of the invention are useful for stimulating TLR signaling, specifically including signaling by TLR7, TLR8, and TLR9. The compounds and pharmaceutical compositions of the invention are also useful in methods for enhancing an immune response, for treating cancer, infection, allergy, and asthma, and for vaccinating a subject. The compounds and pharmaceutical compositions can be used alone, in combination with each other, in combination with an antigen, and in combination with additional therapeutic agents and modalities. |