| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_08e937dc71085c4b2391502fd77a3c8d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3bc2d135e0f46579c8950ca083ff465e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b2ab053dbfb615082ed4797246c6b7b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6913 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 |
| filingDate |
2008-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9678b9bf2ed605300e24d53ae8fa6c55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b920f4a91e0228e3e003ca35abcb5c91 |
| publicationDate |
2009-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009026328-A3 |
| titleOfInvention |
Methods of delivery of agents to leukocytes and endothelial cells |
| abstract |
The present invention generally relates to methods and compositions for the simultaneous delivery of at least one insoluble agent and at least one soluble agent to a cell. In particauar the present invention relates to methods and compositions for the dual delivery of an insoluble agent and a soluble agent to a particular target cell, for example, a leukocyte or endothelial cell. In particular, methods and compositions for simultaneous delivery of a hydrophilic (i.e. soluble) agent and/or a hydrophobic (i.e. insoluble) agent to a leukocyte cell or endothelia cell are disclosed. In one aspect, the present invention provides compositions comprising a targeting moiety that selectively binds one or more integrin ligands on the surface of a leukocyte or endothelial cell; a carrier particle associated with the targeting moiety, wherein the carrier has a lipid phase and an aqueous phase, such as a liposome; an insoluble agent entrapped in the lipid phase of the carrier particle; and/or a soluble agent entrapped in the aqueous phase of the carrier particle. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773395-B1 |
| priorityDate |
2007-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |