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filingDate 2008-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3053bd81376a5c687dda96f29d9e9fea
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publicationDate 2009-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2009025169-A1
titleOfInvention Method for purification of optically active α-fluorocarboxylic acid esters
abstract A method for purification of an optically active α-fluoro- carboxylic acid ester represented by the general formula [1] by removing fluoride ions from the ester to reduce the amount of fluoride ions contained in the ester: [Chemical formula 30] [1] [wherein R1 is alkyl having 1 to 6 carbon atoms; R2 is alkyl having 1 to 4 carbon atoms; and * represents an asymmetric carbon atom], characterized in that the ester is distilled in the presence of an organic base. According to the method, the residual fluoride ion concentration of the optically active α-fluorocarboxylic acid ester can be reduced remarkably by relatively easy operation. It is preferable that the organic base be a tertiary amine, particularly tri-n-butylamine.
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Total number of triples: 41.