| abstract |
A compound represented by the following general formula (I): (wherein A represents optionally substituted aryl or heterocyclic group; B represents optionally substituted aryl or heterocyclic group; X represents C1-5 alkylene or a bond; Y represents C1-5 alkylene optionally having a double bond; Z represents O, S, etc.; R1, R2, and R3 each represents hydrogen, C1-8 alkyl, etc.; R4 represents hydrogen, C1-8 alkyl, etc.; and n and m may be the same or different and each is 1 or 2; provided that when X is a bond, then the substituent which may be possessed by the aryl group represented by A is not alkyl) or a pharmacologically acceptable salt of the compound. The compound or salt is used as a P2X4 receptor antagonist or a preventive or therapeutic agent for neurogenic pains. |