| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b33f5266fabc96b992a8aecafcdcbc32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b1278c9b443cff3824e1ea069cd6350
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85170062a3679ec416d32dfe6454758c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1816 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2008-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f96d2c94bc441590b477e6c46ee2880
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_988ca8716db585203fa7995d9e826611
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e5ea6fbe4954bbcc4ab1a376399eee1 |
| publicationDate |
2009-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009017714-A1 |
| titleOfInvention |
Use of erythropoietin to develop small molecule inhibitors of janus kinase-2 |
| abstract |
The invention pertains to a method for identifying compounds that inhibit the erythropoietin-induced JAK2 kinase activity in vivo. The present invention provides a method for detecting small molecule JAK2 inhibitors in a rapidly created rodent model that phenocopies human PV through Epo stimulation. The method comprises the steps of (a) dosing a rodent with erythropoietin (Epo) and a test compound, (b) collecting blood samples after the dose is administered, (c) measuring phosphorylated STAT5 levels in the blood sample, and (d) determining JAK2 inhibitor levels in the blood samples. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011098673-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017013270-A1 |
| priorityDate |
2007-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |