| abstract |
Disclosed is a pharmaceutical agent which can enhance the production of EPO and is useful for the prevention and/or treatment of anemia. Specifically disclosed are: an EPO production enhancer comprising a 2-phenylquinoline-4-carboxylic acid derivative represented by the general formula (1) [wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group which may have 1 to 3 substituents, a C3-8 cycloalkyl group which may have 1 to 3 substituents or a C1-6 alkoxy group which may have 1 to 3 substituents; and R11 represents a hydrogen atom or a C1-6 alkyl group which may have 1 to 3 substituents], a salt of the derivative, or a solvate of the derivative or the salt; and a prophylactic and/or therapeutic agent for a disease whose condition can be ameliorated by enhancing the production of EPO (particularly, anemia). |