http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009016387-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e522ef22f01c13cd40d52aaee98332c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5053f82a7cd17c60822674b657cfb89e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bd01fb06d2225aa768bff36a8c38fa68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_08bbad165ffa052168d5f066807371c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4df528a427f4bc7e35e5ccd29156f460 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2008-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_214e0e50a093beac20b7fa302e6eef22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f42e4580053c435b861ac9a0d6b757ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_229bc76769eb9143bc84596fb4d0f3b0 |
| publicationDate | 2009-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2009016387-A3 |
| titleOfInvention | Process for the preparation of alfuzosin hydrochloride |
| abstract | A process for preparing alfuzosin or a salt thereof comprising: (a) condensing 4-amino-2- chloro-6,7-dimethoxyquinazoline with 3-methylaminopropionitrile in the presence of a polar aprotic solvent selected from the group consisting of diglyme, dimethyl formamide, t- butanol, hexamethylphosphoramide or mixtures thereof to form N-(4-amino-6,7- dimethoxyquinazol-2-yl)-N-methyl-2-cyanoethylamine (b) hydrogenating the N-(4-amino- 6,7-dimethoxyquinazol-2-yl)-N-methyl-2-cyanoethylamine using a hydrogenating agent under a pressure of less than 10 kg/cm2 to form N-(4-amino-6,7-dimethoxyquinazol-2-yl)- N-methylpropylenediamine and optionally converting the N-(4-amino-6,7- dimethoxyquinazol-2-yl)-N-methylpropylenediamine to an acid addition salt thereof; and (c) converting tetrahydrofuroic acid to an intermediate form and condensing the intermediate form with the N-(4-amino-6,7-dimethoxyquinazol-2-yl)-N-methylpropylenediamine or with the acid addition salt to yield alfuzosin base, and optionally converting alfuzosin base to a salt of alfuzosin. |
| priorityDate | 2007-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.