| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff6ab0942a695eeed73a77d55a07c487
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b087828517e3bac783268125ed89d88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c13728b37d6d54d1f24921d5d897339
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01a96e8bbea00eeaa0b50c2a0c000dba |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate |
2008-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b03d2ff752a3dfc86d9797c4dceaaf5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_340d61c45dcd59a80fcb812d32e5fbd3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc8a20dced76d8bb51781c41c704bb8c |
| publicationDate |
2009-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009011870-A1 |
| titleOfInvention |
Reduction of beta-amyloid levels by treatment with the small molecule differentiation-inducing factor |
| abstract |
The present invention relates to novel uses for a family of small molecules, Differentiation-Inducing Factors (DIFs). It has been discovered that DIFs surprisingly can alter the metabolic processing of amyloid precursor protein (APP) and in turn reduce the level of secreted Aβ. The metabolic processing of other γ-secretase substrates normally present in cells (Notch and APLPl) is not affected when treated with DIF. The invention provides methods for reducing Aβ production in mammalian cells that express APP by administering DIF-I, DIF-2, DIF-3, a functionally equivalent analog and or any combination thereof. The invention also provides methods for treating and/or preventing Alzheimer's disease by preferentially reducing Aβ production. |
| priorityDate |
2007-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |