| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd1d017c9fa5619879ab770e9987e922
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_91d518822a07bf4f8e03d91bb8845af6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59c9c87fa14166f9b6af9dfdcb48cec7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f95e45fd68a57404ee589cb5f9283ecf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f474389335113cca27cbc5308b5e6268
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c44c2b7f71c19ae4a88dd50b8180b51f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f0addd7bd30ed6d7d6b9c4f5d9c6cc57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd5e5cf13b3b87b366a8d558bf8c17a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e8835063b34c94d51ce16062666fea8f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-27 |
| filingDate |
2008-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94caa2a061bda904b8369167d6e0e7e7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5c3a42803709e97b3c24f98db67189b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60d227fb1732815723d93f6380deb4ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7c54825b824e50b669f447c2feffbeb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6deb7dc32ae3d52572dd5b2934ebecd9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d58abe7a91094bb262fb1bac8c4b4945
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27567a59862707b350ba5e60965dc6ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc7715505f6be6b086a457672cabd38c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34972b19b4e14c3a110fe1488b88baad |
| publicationDate |
2009-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009009449-A3 |
| titleOfInvention |
Phospholipase a2 inhibitors and their use in treating neurological injury and disease |
| abstract |
Phospholipase A2 (PLA2) forms are expressed in spinal cord whose inhibition induces a potent antihyperalgesia. PLA2 inhibitor compounds are provided that include a common motif consisting of a 2-oxoamide with a hydrocarbon tail and a four carbon tether. The compounds block Group IVA calcium dependent PLA2 (cPLA2) and/or Group VIA calcium independent PLA2 (iPLA2) and/or Group V secreted PLA2 (sPLA2). Pharmaceutical compositions of compounds having cPLA2 inhibitory activity (but not iPLA2 or sPLA2 inhibitory activity) are useful in treating multiple sclerosis, while compositions of compounds having sPLA2 inhibitory activity (as well as iPLA2 and CPLA2 activity) are useful in treating spinal cord injuries (with related functional recovery). |
| priorityDate |
2007-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |