| abstract |
Methods of contacting two or more immiscible liquids comprising providing a unitary thermally-tempered microstructured fluidic device [10] comprising a reactant passage [26] therein with characteristic cross-sectional diameter [11] in the 0.2 to 15 millimeter range, having, in order along a length thereof, two or more inlets [A, B or A, B1] for entry of reactants, an initial mixer passage portion [38] characterized by having a form or structure that induces a degree of mixing in fluids passing therethrough, an initial dwell time passage portion [40] characterized by having a volume of at least 0.1 milliliter and a generally smooth and continuous form or structure and one or more additional mixer passage portions [44], each additional mixer passage portion followed immediately by a corresponding respective additional dwell time passage portion [46]; and flowing the two or more immiscible fluids through the reactant passage, wherein the two or more immiscible fluids are flowed into the two or more inlets [A, B or A, B1] such that the total flow of the two or more immiscible fluids flows through the initial mixer passage portion [38]. Unitary devices [10] in which the method may be performed are also disclosed. |