abstract |
Disclosed is a catalyst composition for cross-coupling reaction, which contains a nickel metal source, a fluorine source, and a nitrogen-containing heterocyclic compound having a specific structure or a phosphine compound. By reacting an organic metal compound represented by the following formula (2): R5-MY1 or the following formula (3): R5-M-R5 (wherein R5 represents an aryl group, a heteroaryl group, a linear, branched or cyclic alkyl group, or a linear, branched or cyclic alkenyl group; M represents an Mg atom or a Zn atom; and Y1 represents a halogen group) with a compound represented by the following formula (4): R6-Y2 (wherein R6 represents an aryl group, a heteroaryl group, a linear, branched or cyclic alkyl group, or a linear, branched or cyclic alkenyl group; and Y2 represents a halogen atom, a methane sulfonate group, a toluene sulfonate group or a trifluoromethane sulfonate group) in the presence of such a catalyst composition, there can be obtained a cross-coupling compound R5-R6 with high selectivity. |